A survey on coronary heart disease related signal pathways, drug targets and pharmacological interventions

DOI: 10.5584/jiomics.v2i2.105

Abstract

Coronary heart disease (CHD), the most common form of cardiovascular disease, is a chronic, multifactorial disease. With significant advances in our understanding of the pathophysiological process of CHD in recent years, more and more drug targets have been identified and adopted in drug discovery for CHD. Purpose and methods: In this review, a comprehensive perspective of pathological and pharmacological development of CHD was introduced through searching in multiple bibliographic sources. Results: CHD related signal pathways (including 412 proteins), drug targets (including 101 proteins) and pharmacological interventions were summarized and visualized. Conclusions: The knowledge of these signal pathways and drug targets may facilitate new drug discovery and medicine intervention for CHD in the future.