Journal of Integrated OMICS https://www.jiomics.com/index.php/jiomics <div class="mainrow"> <div class="homeImageMini">JIOMICS provides a forum for the publication of original research papers, letters to the editor, short communications, and critical reviews in all branches of pure and applied –omics subjects, such as proteomics, metabolomics, metallomics and genomics. Especial interest is given to papers where more than one –omics subject is covered. Papers are evaluated based on scientific novelty and demonstrated scientific applicability. Original research papers on fundamental studies, and novel sensor and instrumentation development, are especially encouraged. Novel or improved findings in areas such as clinical, medicinal, biological, environmental and materials –omics are welcome.</div> <div class="homeImageMini"> <div class="homeImageMini"> </div> <div class="homeDescription"> <table style="height: 144px; width: 100%; border-collapse: collapse;" border="0"> <tbody> <tr style="height: 18px;"> <td style="width: 50%; height: 18px;"><a href="https://www.jiomics.com/index.php/jiomics/issue/current">Current Issue</a></td> <td style="width: 50%; height: 18px; text-align: right;"><a href="https://www.jiomics.com/index.php/jiomics/issue/archive">Previous issues</a></td> </tr> <tr style="height: 18px;"> <td style="width: 50%; height: 18px;"><a href="https://www.jiomics.com/index.php/jiomics/issue/archive">Accepted manuscripts</a></td> <td style="width: 50%; height: 18px; text-align: right;"><a href="https://www.jiomics.com/index.php/jiomics/about">Editorial Board</a></td> </tr> <tr style="height: 18px;"> <td style="width: 50%; height: 18px;"><a href="https://www.jiomics.com/index.php/jiomics/about/submissions#onlinesubmissions">Guide for authors</a></td> <td style="width: 50%; height: 18px; text-align: right;"><a href="https://www.jiomics.com/index.php/jiomics/about/submissions#templateforonlinesubmissions">Template for submissions</a></td> </tr> <tr style="height: 18px;"> <td style="width: 50%; height: 18px;"><a href="https://www.jiomics.com/index.php/jiomics/about/submissions#templateforonlinesubmissions">JIOMICS references format</a></td> <td style="width: 50%; height: 18px; text-align: right;"><a href="https://www.jiomics.com/index.php/jiomics/about/submissions#authorfees">Fees</a></td> </tr> </tbody> </table> </div> </div> </div> en-US jlcapelom@proteomass.org (Jose Luis Capelo Martínez) jlcapelom@proteomass.org (Jose Luis Capelo Martínez) Thu, 31 Oct 2024 00:00:00 +0000 OJS 3.2.1.2 http://blogs.law.harvard.edu/tech/rss 60 Computational Screening of Natural Compounds as Antiviral Candidates Targeting the SARS-CoV-2 Main Protease https://www.jiomics.com/index.php/jiomics/article/view/234 <p>The onset of the global pandemic caused by Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) in Wuhan in December 2019 has led to an urgent need for effective preventive and therapeutic solutions. Among the various approaches explored, natural products have shown potential in the fight against COVID-19. This study employed computational techniques to screen and evaluate six natural antiviral compounds for their effectiveness against the SARS-CoV-2 Main Protease (M<sup>pro</sup>). By using molecular docking simulations, the interactions between these natural compounds and the target proteins were predicted and analyzed, focusing on factors such as binding affinity, interaction patterns, and structural compatibility within the active sites. The analysis indicated that Cladosin C and Rhodatin formed the most stable interactions with M<sup>pro</sup>, engaging with several critical residues. Cannabidiol, Capsaicin, and Kappa-Carrageenan also demonstrated promising interactions, though with some variability. On the other hand, Astaxanthin exhibited the least stable binding, suggesting limited antiviral potential. This research provides insights into the possible roles of these natural compounds as antagonists of the SARS-CoV-2 M<sup>pro</sup> enzyme. Further in vitro and in vivo studies are necessary to confirm the antiviral properties of these compounds, and future research should investigate their broader antiviral applications.</p> Ilyes Zatla Copyright (c) 2024 Journal of Integrated OMICS https://creativecommons.org/licenses/by/4.0 https://www.jiomics.com/index.php/jiomics/article/view/234 Thu, 31 Oct 2024 00:00:00 +0000 Editorial Forensics https://www.jiomics.com/index.php/jiomics/article/view/236 José Luís Capelo Martínez Copyright (c) 2024 Journal of Integrated OMICS https://creativecommons.org/licenses/by/4.0 https://www.jiomics.com/index.php/jiomics/article/view/236 Thu, 31 Oct 2024 00:00:00 +0000 Vol 14 NO. 3 (2024) https://www.jiomics.com/index.php/jiomics/article/view/237 José Luís Capelo Martínez Copyright (c) 2024 Journal of Integrated OMICS https://creativecommons.org/licenses/by/4.0 https://www.jiomics.com/index.php/jiomics/article/view/237 Thu, 31 Oct 2024 00:00:00 +0000