S-glutathionylation of proteins in various types of neurodegenerative pathology and protective effects of pantothenic acid derivatives

DOI: 10.5584/jiomics.v10i1.307

Abstract

We studied changes in S-glutathionylated proteins (PSSG) content in rat brain structures in different experimental models of neurodegenerative pathology, as well as the possibility of correcting these changes with pantothenic acid derivatives. We have shown that the content of PSSG significantly increases in brain structures in all the models of neurotoxicosis that we studied, and this increase is observed to the greatest extent precisely in those structures where a particular neurotoxin has the most pronounced effect. Thus, the content of PSSG is a sensitive marker of post-translational protein modification. Precursors of CoA reduce S-glutathionylation of proteins, since HPA, which is not a precursor of CoA, does not have a protective effect in relation to PSSG.