The potential benefits of shRNA-mediated MMP1 silencing for psoriasis
Matrix metalloproteinases (MMPs) orchestrate structural remodeling of psoriatic skin and accelerate the development of the inflammatory response.
In this paper, we explore whether knocking MMP1 down in epidermal keratinocytes can be beneficial for psoriasis.
We discovered that MMP1 silencing with specific shRNA reduced the migration of epidermal keratinocytes and made the cells susceptible to apoptosis in the presence of interferon-γ. Furthermore, MMP1-deficiency partially normalized the expression of genes involved in the pathogenesis of psoriasis (MMP9, -12, CCNA2, CCND1 and KRT17) and the terminal differentiation (KRT1, -10, IVL and LOR).
In this respect, MMP1 silencing could be beneficial for psoriasis due to MMP1 expression is limited to psoriatic plaques and correlates with disease severity.